Jeffrey Lyons began his training in Lake Charles, Louisiana when he was eleven years old. He later trained at American Ballet Theatre School. He began his professional career as a member of American Ballet Theatre II and Pittsburgh Ballet Theatre. In 1989, Lyons joined Pennsylvania Ballet where he danced a varied repertory. When he retired from the stage in 1996, Lyons joined the faculty of The Rock School for Dance Education. Lyons joined the faculty of San Francisco Ballet School in 1999.
Lyons joined San Francisco Ballet as a principal character dancer for the 2023-24 Season.